Well, my first real job out of college was at a law firm, where I had moved from paralegal to administrator. People (even non-lawyers) stayed at this place for 15+ years - my boss had been there for 40. I didn't like what I was doing there and most of the people I could tolerate had left, so I found a new job doing something completely different.

Most people outside of my immediate supervisors applauded me for making the change and wished me luck. The people I worked directly with went batshit because they didn't even know what questions to ask me about what I was doing to be able to cover it. My boss basically gave me silent treatment the entire two weeks.